Approved Uses

Otezla (apremilast) is a prescription medicine approved for the treatment of patients with moderate to severe plaque psoriasis for whom phototherapy or systemic therapy is appropriate.

Otezla is a prescription medicine approved for the treatment of adult patients with active psoriatic arthritis.

Otezla is a different kind of treatment Close
A pill that can help
you achieve clearer skin

Treat plaque psoriasis differently

Treat psoriatic arthritis differently

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Otezla for plaque psoriasis
Otezla for psoriatic arthritis
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*Certain restrictions apply. *Certain restrictions apply; eligibility not based on income.

APPROVED USES

Otezla® (apremilast) is a prescription medicine approved for the treatment of patients with moderate to severe plaque psoriasis for whom phototherapy or systemic therapy is appropriate.

Otezla is a prescription medicine approved for the treatment of adult patients with active psoriatic arthritis.

IMPORTANT SAFETY INFORMATION

You must not take Otezla if you are allergic to apremilast or to any of the ingredients in Otezla.

Otezla can cause severe diarrhea, nausea, and vomiting, especially within the first few weeks of treatment. Use in elderly patients and the use of certain medications with Otezla appears to increase the risk of having diarrhea, nausea, or vomiting. Tell your doctor if any of these conditions occur.

Otezla is associated with an increase in depression. In clinical studies, some patients reported depression, or suicidal behavior while taking Otezla. Some patients stopped taking Otezla due to depression. Before starting Otezla, tell your doctor if you have had feelings of depression, or suicidal thoughts or behavior. Be sure to tell your doctor if any of these symptoms or other mood changes develop or worsen during treatment with Otezla.

Some patients taking Otezla lost body weight. Your doctor should monitor your weight regularly. If unexplained or significant weight loss occurs, your doctor will decide if you should continue taking Otezla.

Some medicines may make Otezla less effective, and should not be taken with Otezla. Tell your doctor about all the medicines you take, including prescription and nonprescription medicines.

Side effects of Otezla include diarrhea, nausea, vomiting, upper respiratory tract infection, runny nose, sneezing, or congestion, abdominal pain, tension headache, and headache. These are not all the possible side effects with Otezla. Ask your doctor about other potential side effects. Tell your doctor about any side effect that bothers you or does not go away.

Tell your doctor if you are pregnant, planning to become pregnant or planning to breastfeed. Otezla has not been studied in pregnant women or in women who are breastfeeding.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-332-1088.

Please click here for Full Prescribing Information.

Side effects & safety info

Do not take Otezla if you are allergic to apremilast or to any of the ingredients in Otezla.

Severe diarrhea, nausea, and vomiting have been reported with Otezla. Most of these events occurred within the first few weeks of treatment. Elderly patients and patients using Otezla with certain medications such as those used to lower blood pressure may be at higher risk. Tell your doctor if you experience severe diarrhea, nausea, or vomiting. Your doctor may lower your dose or stop your treatment with Otezla.

Some patients taking Otezla reported depression. Before starting Otezla, tell your doctor if you have had feelings of depression, suicidal thoughts, or suicidal behavior. After starting Otezla, tell your doctor if any of these symptoms, or other mood changes, develop or worsen.

Some patients taking Otezla lost body weight. Your doctor should monitor your weight regularly. If unexplained or significant weight loss occurs, your doctor will decide if you should continue taking Otezla.

You should not take certain medicines when you are taking Otezla as they may decrease its effectiveness.

Tell your doctor if you are pregnant, planning to become pregnant or planning to breastfeed.

Common side effects of Otezla

The most common side effects of Otezla were diarrhea, nausea, upper respiratory tract infection, tension headache, and headache.

Most people reporting nausea and diarrhea did so within the first 2 weeks of treatment; these side effects tended to go away over time without stopping Otezla. Tell your doctor if any of these occur.

These are not all the possible side effects with Otezla. Tell your doctor about any side effect that bothers you or does not go away.

If you are experiencing side effects, please consult your doctor.

For more information, please see Important Safety Information to the right of this page.

Percentage of people who experienced diarrhea over time
(during clinical trials)

Percentage of people who experienced nausea over time
(during clinical trials)

Percentage of people who experienced diarrhea over time
(during clinical trials)

Otezla clinical studies involved 1,426 adults with moderate to severe plaque psoriasis who were candidates for phototherapy or systemic therapy.

Percentage of people who experienced nausea over time
(during clinical trials)

Otezla clinical studies involved 1,426 adults with moderate to severe plaque psoriasis who were candidates for phototherapy or systemic therapy.

Speak up about side effects

Talk to your dermatologist about any side effects that bother you or do not go away. Your dermatologist may be able to suggest ways to help manage your symptoms.

Before After

Results with Otezla

See before and after photos of people taking Otezla as their plaque psoriasis treatment.

Individual results may vary.

See all before & after photos
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*Certain restrictions apply. *Certain restrictions apply; eligibility not based on income.

APPROVED USES

Otezla® (apremilast) is a prescription medicine approved for the treatment of patients with moderate to severe plaque psoriasis for whom phototherapy or systemic therapy is appropriate.

Otezla is a prescription medicine approved for the treatment of adult patients with active psoriatic arthritis.

IMPORTANT SAFETY INFORMATION

You must not take Otezla if you are allergic to apremilast or to any of the ingredients in Otezla.

Otezla can cause severe diarrhea, nausea, and vomiting, especially within the first few weeks of treatment. Use in elderly patients and the use of certain medications with Otezla appears to increase the risk of having diarrhea, nausea, or vomiting. Tell your doctor if any of these conditions occur.

Otezla is associated with an increase in depression. In clinical studies, some patients reported depression, or suicidal behavior while taking Otezla. Some patients stopped taking Otezla due to depression. Before starting Otezla, tell your doctor if you have had feelings of depression, or suicidal thoughts or behavior. Be sure to tell your doctor if any of these symptoms or other mood changes develop or worsen during treatment with Otezla.

Some patients taking Otezla lost body weight. Your doctor should monitor your weight regularly. If unexplained or significant weight loss occurs, your doctor will decide if you should continue taking Otezla.

Some medicines may make Otezla less effective, and should not be taken with Otezla. Tell your doctor about all the medicines you take, including prescription and nonprescription medicines.

Side effects of Otezla include diarrhea, nausea, vomiting, upper respiratory tract infection, runny nose, sneezing, or congestion, abdominal pain, tension headache, and headache. These are not all the possible side effects with Otezla. Ask your doctor about other potential side effects. Tell your doctor about any side effect that bothers you or does not go away.

Tell your doctor if you are pregnant, planning to become pregnant or planning to breastfeed. Otezla has not been studied in pregnant women or in women who are breastfeeding.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-332-1088.

Please click here for Full Prescribing Information.

Important Safety Information

See more

You must not take Otezla if you are allergic to apremilast or to any of the ingredients in Otezla.

Otezla can cause severe diarrhea, nausea, and vomiting, especially within the first few weeks of treatment. Use in elderly patients and the use of certain medications with Otezla appears to increase the risk of having diarrhea, nausea, or vomiting. Tell your doctor if any of these conditions occur.

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