Approved Uses

Otezla (apremilast) is a prescription medicine approved for the treatment of patients with moderate to severe plaque psoriasis for whom phototherapy or systemic therapy is appropriate.

Otezla is a prescription medicine approved for the treatment of adult patients with active psoriatic arthritis.

Otezla is a different kind of treatment Close
A pill that can help
you achieve clearer skin

Treat plaque psoriasis differently

Treat psoriatic arthritis differently

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Otezla for plaque psoriasis
Otezla for psoriatic arthritis
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*Certain restrictions apply. *Certain restrictions apply; eligibility not based on income.

APPROVED USES

Otezla® (apremilast) is a prescription medicine approved for the treatment of patients with moderate to severe plaque psoriasis for whom phototherapy or systemic therapy is appropriate.

Otezla is a prescription medicine approved for the treatment of adult patients with active psoriatic arthritis.

IMPORTANT SAFETY INFORMATION

You must not take Otezla if you are allergic to apremilast or to any of the ingredients in Otezla.

Otezla can cause severe diarrhea, nausea, and vomiting, especially within the first few weeks of treatment. Use in elderly patients and the use of certain medications with Otezla appears to increase the risk of having diarrhea, nausea, or vomiting. Tell your doctor if any of these conditions occur.

Otezla is associated with an increase in depression. In clinical studies, some patients reported depression, or suicidal behavior while taking Otezla. Some patients stopped taking Otezla due to depression. Before starting Otezla, tell your doctor if you have had feelings of depression, or suicidal thoughts or behavior. Be sure to tell your doctor if any of these symptoms or other mood changes develop or worsen during treatment with Otezla.

Some patients taking Otezla lost body weight. Your doctor should monitor your weight regularly. If unexplained or significant weight loss occurs, your doctor will decide if you should continue taking Otezla.

Some medicines may make Otezla less effective, and should not be taken with Otezla. Tell your doctor about all the medicines you take, including prescription and nonprescription medicines.

Side effects of Otezla include diarrhea, nausea, vomiting, upper respiratory tract infection, runny nose, sneezing, or congestion, abdominal pain, tension headache, and headache. These are not all the possible side effects with Otezla. Ask your doctor about other potential side effects. Tell your doctor about any side effect that bothers you or does not go away.

Tell your doctor if you are pregnant, planning to become pregnant or planning to breastfeed. Otezla has not been studied in pregnant women or in women who are breastfeeding.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-332-1088.

Please click here for Full Prescribing Information.

Getting started with Otezla

Recently prescribed or considering Otezla for psoriasis treatment? Here’s what you need to know about this pill for psoriasis.

The Otezla Prescribing Information has no requirement for blood tests, so once your doctor prescribes you Otezla, you can start treatment right away.

Otezla dosing

Otezla is an oral medication, meaning it's taken by mouth every day, once in the morning, and once at night. For example, you can take Otezla with breakfast and dinner each day, or after you brush your teeth in the morning and at night. You can take Otezla with or without food. Do not crush, split, or chew the pill.

On your first day, you only take one pill. For people with severe kidney disease, Otezla is one pill a day. Be sure to take Otezla as directed by your doctor.

Your first week on Otezla

Conveniently, your Otezla prescription will be sent right to your doorstep each month. (That means no trip to the pharmacy to pick it up.) 

When you first start treatment, you’ll have a 5-day titration period, which means that you’ll gradually increase your dose over your first 5 days until you reach the recommended dose. People with severe kidney disease will follow a different schedule for their titration period.

  DAY 1 DAY 2 DAY 3 DAY 4 DAY 5 DAY 6 &
BEYOND
AM 10 mg 10 mg 10 mg 20 mg 20 mg 30 mg
PM — 10 mg 20 mg 20 mg 30 mg 30 mg

This titration is meant to help reduce the gastrointestinal symptoms related to initial treatment with Otezla.

little roll

big deal

Speak up about side effects

Talk to your dermatologist about any side effects that bother you or do not go away. Your dermatologist may be able to suggest ways to help manage your symptoms.

Otezla delivery

Your Otezla prescription will be filled by a specialty pharmacy and shipped straight to your door. Never worked with a specialty pharmacy before?

Getting your Otezla

Save on treatment

Eligible people can pay $0 a month for their Otezla prescription—and for those not eligible, other savings opportunities are available.

Savings & coverage

Gotezla

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*Certain restrictions apply. *Certain restrictions apply; eligibility not based on income.

APPROVED USES

Otezla® (apremilast) is a prescription medicine approved for the treatment of patients with moderate to severe plaque psoriasis for whom phototherapy or systemic therapy is appropriate.

Otezla is a prescription medicine approved for the treatment of adult patients with active psoriatic arthritis.

IMPORTANT SAFETY INFORMATION

You must not take Otezla if you are allergic to apremilast or to any of the ingredients in Otezla.

Otezla can cause severe diarrhea, nausea, and vomiting, especially within the first few weeks of treatment. Use in elderly patients and the use of certain medications with Otezla appears to increase the risk of having diarrhea, nausea, or vomiting. Tell your doctor if any of these conditions occur.

Otezla is associated with an increase in depression. In clinical studies, some patients reported depression, or suicidal behavior while taking Otezla. Some patients stopped taking Otezla due to depression. Before starting Otezla, tell your doctor if you have had feelings of depression, or suicidal thoughts or behavior. Be sure to tell your doctor if any of these symptoms or other mood changes develop or worsen during treatment with Otezla.

Some patients taking Otezla lost body weight. Your doctor should monitor your weight regularly. If unexplained or significant weight loss occurs, your doctor will decide if you should continue taking Otezla.

Some medicines may make Otezla less effective, and should not be taken with Otezla. Tell your doctor about all the medicines you take, including prescription and nonprescription medicines.

Side effects of Otezla include diarrhea, nausea, vomiting, upper respiratory tract infection, runny nose, sneezing, or congestion, abdominal pain, tension headache, and headache. These are not all the possible side effects with Otezla. Ask your doctor about other potential side effects. Tell your doctor about any side effect that bothers you or does not go away.

Tell your doctor if you are pregnant, planning to become pregnant or planning to breastfeed. Otezla has not been studied in pregnant women or in women who are breastfeeding.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-332-1088.

Please click here for Full Prescribing Information.

Important Safety Information

See more

You must not take Otezla if you are allergic to apremilast or to any of the ingredients in Otezla.

Otezla can cause severe diarrhea, nausea, and vomiting, especially within the first few weeks of treatment. Use in elderly patients and the use of certain medications with Otezla appears to increase the risk of having diarrhea, nausea, or vomiting. Tell your doctor if any of these conditions occur.

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